Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities.Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly relapse with reactivation of the targeted pathways.We identify the nuclear protein SFPQ to be syntheti
Objective: Next-generation sequencing (NGS)-based technologies are novel methodologies for the diagnosis, prognostic assessment and decision of individualized treatment strategy in hematological neoplasia.NGS led to a more comprehensive understanding of the mutational landscape, especially in the myeloid neoplasms.Herein, we present the results of
Cells of undomesticated species of Bacillus subtilis frequently form complex colonies during spreading on agar surfaces.Given that menaquinone is involved in another form laguna 3hp dust collector of coordinated behavior, namely, sporulation, we looked for a possible role for menaquinone in complex colony development (CCD) in the B.subtilis strain
This work addresses the analysis and characterization of deadlocks in discrete-event systems modeled by labeled Petri nets (LPNs) with undistinguishable and unobservable transitions.To provide a solution for the notorious problem, it is essential to present an effective characterization in such a way that deadlock laguna 3hp dust collector control